Superoxide dismutase (SOD) catalyzes the breakdown of the superoxide ion to dioxygen and hydrogen peroxide to prevent oxidative damage. One form of SOD contains nickel coordinated to two amido nitrogens, two cysteinate sulfurs, and a pendant imidazole nitrogen. This research project focuses on modeling the structure and function of the enzyme using a diamino, dithiolate nickel complex with a pendant alcohol arm. The synthesis and characterization of this complex will be presented along with preliminary reactivity data.

Nickel dithiolate complex as a potential model for Ni-containing superoxide dismutase

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.