Ribosomally synthesized and post-translationally modified peptides (RiPPs) are known for their macrocyclic structures which impart unique biological activity. One rapidly emerging subclass of RiPP natural products contains macrocyclic C−C crosslinks between two amino acid side chains. These linkages, often biosynthetically formed by a single rSAM or P450 enzyme, introduce significant structural and synthetic complexity to the molecules. While nature utilizes elegant mechanisms to produce C−C crosslinked RiPPs, synthetic tools are only able to access a small number of these biologically relevant natural products, and remain underdeveloped. In this talk, the development of new strategies and reactions inspired by, and for the synthesis of C-C cross-linked RiPPs will be presented.

New strategies and reactions inspired by C-C cross-linked RiPP natural products

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