Gold nanoparticles represent an established platform for the delivery of drugs and nucleic acids to cells. Important advantages such as biocompatibility, density, and special physicochemical, optical and surface properties propelled gold nanoparticles in a plethora of biological applications, most of them in vitro or ex vivo. However, the translation to in vivo applications seemed to be problematic in many cases due to suboptimal ligand stability that affects the colloidal stability of the platform and its delivery properties. In this context we will present our most recent results towards control of synthesis, decoration with specific ligands and ligand stability under a wide range of conditions, with the goal of generating robust gold nanoplatforms for drug delivery.

Gold nanoparticles synthesis, ligand exchange and cargo loading optimization for drug delivery

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ACS Spring 2023

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