TCFH (tetramethylchloroformamidinium hexafluorophosphate) has been shown to be a relatively green coupling reagent for the rapid and mild formation of challenging amide bonds. TCFH has the additional advantage of not being a sensitizer, unlike commonly used coupling reagents such as EDAC, DCC, and HBTU. This poster will present further applications and optimizations of TCFH in mild, green coupling reactions with hindered and electron-poor substrates.

TCFH as a mild, green, non-sensitizing coupling reagent

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