Ion-sensing by triazole compounds has been promising in recent times. They are able to selectively detect heavy metal ions (e.g., Cu2+ and Al3+) and anions (e.g., F-, H2PO4-, and OAc-) in aqueous and organic media chemo-/fluorometrically. In our research, this detection capability is extended to understand triazole molecule’s sensing behavior in biomimicking environments. We created model systems using organized self-assemblies in the purview of using small organic molecules as prodrugs for early detection of fluoride and copper overexposure in physiological environments. Micelles, liposomes, cyclodextrins, and polymeric nanomaterials are known to simulate biological environments (DNA, protein, etc.) thereby executing biocompatibility to transport drug molecules to the targeted site. They also provide a space for drug solubilization. Our recent work studies triazole molecule’s encapsulation process and binding behavior in such colloidal assemblies by monitoring the photophysical modifications in non-ionic, cationic, and anionic micelles as well as in cyclodextrins. The physicochemical changes of the molecules within the micelle environment were evaluated using fluorescence spectroscopy. This technique helped to detect and determine the positioning of the triazole derivatives in different non-ionic micellar media. A differential interaction between the triazole molecules and these organized assemblies was observed indicating a location variance, from the micelle-water interface to the micellar core area. Further inquiries on the hydrodynamic size and surface morphology are underway.

Journey of triazole derivatives from dual ion-sensing to model drug delivery system

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