Nanocellulose, more especially cellulose nanofibrils (CNFs), are materials of great interest and some research recently focused on its use for biomedical application. The combination of CNFs and β-CDs is recent and promising. Previous works have shown the strong impact on classic CNF to prolong the release of drugs. Understanding of the physico-chemical interactions and the conformation organization onto the fibre is still tricky and only few consider using the CD derivatives. The combination of oxidized cellulose nanofibrils (toCNFs) and various β-cyclodextrins (β-CDs) to design improved materials for biomedical applications have been achieved very recently. Thus, this project aims at developing innovative materials and characterizing the adsorption phenomena and improving drug release of poorly-water soluble active principal ingredient (API) and consequently prolonging antimicrobial properties. First, the production of toCNF/β-CD materials was reported, with an investigation on the impact of process parameters on presence of CD derivatives on water sorption and mechanical properties. In this field, researchers faces some challenges, notably characterization of this association. In this study, the adsorption of β-CDs was characterized via different experimental tools confirming that β-CD derivatives adsorb up to 10 times more onto toCNF than β-CD. Finally, the functionalization of toCNF with β-CD derivatives showed improvement of the antimicrobial properties of films with a clear increased of efficiency, especially for carboxymethylated-β-CD. The results contribute to the knowledge on interaction of cyclodextrin and nanocellulosic materials and are a step-towards their efficient application in biomedical field as well as other applications such as depollution.

Adsorption of β-cyclodextrins and derivatives onto cellulose nanofibril for designing drug release materials

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