Derivatives of polycyclic aromatic hydrocarbons that belong to the quinonoidal family represent the second largest class of clinically approved anticancer drugs. In the present research we have synthesized and characterized hydrazone derivatives of distinct ortho quinones and studied their biological activities. We evaluated the in vitro antiproliferative activity of the synthesized compounds against human lung cancer (A549) and ovarian cancer (OVCAR8) cells using standard sulforhodamine B colorimetric (SRB) Assay. We assessed the mechanism behind the cell apoptosis using the Western blot assay to measure the levels of Caspase-3, a family of cysteine-dependent aspartate-directed proteases which plays a critical role in the transduction of apoptosis

<i>In vitro</i> toxicological testing of quinone derivatives against human lung and ovarian cancer cell lines

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In vitro toxicological testing of quinone derivatives against human lung and ovarian cancer cell lines