Rhodamine B is a commercially available fluorescent dye based on a xanthene core that can be used as a staining reagent. Amide derivatives of rhodamine B have found applications in fluorescent sensors for metal ions and as a method to conjugate the dye to biomolecules for use as bio markers. We are interested how forming dimers of rhodamine B amides may impact the subsequent optical properties. A library of rhodamine B covalent dimers have been synthesized using different diamine linkers, including aryl and alkyl diamines that vary in flexibility. These dimers have been characterized using nuclear magnetic resonance (NMR), liquid chromatography-mass spectroscopy (LCMS), ultraviolet-visible spectroscopy (UV-vis) and fluorescence spectroscopy. In this presentation, specific aspects of the synthetic procedure will be discussed, as well as the primary differences of the dimers in the library.

Synthesizing and characterizing a library of rhodamine B amide dimers with varying covalent linkers

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