The alcohol functional group is converted into monotosylate. Tosylation has a huge impact on organic synthesis for a variety of functional group interconversion. The Tosyl group also plays an important role in bioconjugation like oligonucleotide chemistry and amino acid chemistry. Glycols and diols were tosylates under controlled and mild conditions. The complete consumption of tosyl chloride was monitored by TLC then the reaction mixture was extracted to remove excess glycols or diols and pyridinium salt. The majority of ditosylated bi-product and remaining pyridine were removed by precipitation. Tosylate derivatives of glycol and diols were synthesized with a higher overall yield. Products were analyzed with TLC and ESI. The product does not require any expensive flash column chromatographic separation.

TLC and LC-MS monitoring chromatography free synthesis of monotosylation of glycols and diols

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