Biopolymers are an attractive avenue for drug delivery applications due to their abundance, biocompatibility, sustainability, and flexible modification. Cellulose-based materials are especially appealing, but their development is often hampered by the poor solubility of their parent polymer. Hydrophobic groups can be reversibly grafted onto a biopolymer to make oxidation-sensitive solubility-switching materials. Different reactive oxidation species (ROS) were substituted on cellulose to make hydrogen peroxide-responsive hydrophobic films and microparticles. The modified cellulose was prepared through a solution-phase reaction. The modified polymer could be fashioned into particles or films, which were investigated to encapsulate hydrophobic cargo and release the payload under oxidizing conditions. The new material may hold promise in drug-eluting depot formations like stents, sutures, or beads.

Oxidation-responsive modified cellulose-based materials

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.