Interest in research of drug delivery systems based in nanomaterials is growing due to their biomedical applications. Silver and gold nanoparticles have demonstrated important properties in antimicrobial and anticancer activities. Bimetallic nanoparticles combined the properties of both metals, providing improved characteristics than the individual metals. In this research, we report the synthesis of bimetallic silver-gold core shell by green and conventional methods for drug coating. For the green way, different extraction techniques for Moringa Oleifera (MO) leaves were applied including Soxhlet, Magnetic Stirring and Ultrasound-Assisted Extraction (UAE). For the green nanoparticles synthesis salt precursors of HAuCl<sub>4 </sub>and AgNO<sub>3</sub> were used with different MO extracts varying the kinetic parameters. For the conventional method we prepare the core shell by the reduction of silver nitrate (AgNO3) with sodium borohydride (NaBH4) and (HAuCl4) with sodium citrate and polyethylene glycol to stabilize the nanoparticles. The particles were characterized by performing Dynamic Light Scattering (DLS) with zeta potential and UV-Vis spectroscopy. These nanoparticles exhibit a peak around 523 nm (for conventional method) and 550 nm for green synthesis. The size distribution was 60-70 nm. The surface of nanoparticles will be modified to be functionalized with different therapeutic drugs. For future works morphological studies using Scanning Electron microscopy will be performed

Design and stability of green bimetallic nanoparticles of Au@Ag for drug delivery studies: Comparison with conventional methods

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