Polysaccharide-based Schiff base hydrogels are promising for biomedical applications including drug delivery, wound dressing, and tissue engineering. We made pH-responsive, injectable, and self-healing hydrogels using oxidized hydroxypropyl cellulose (Ox-HPC) and carboxymethyl chitosan (CMCS). The reversible nature of the imine bond linkage provides hydrogels with injectable and self-healing properties. Phenylalanine as a model amine-containing drug was chemically bonded to Ox-HPC within the hydrogel. Phenylalanine release was faster at the tumor tissue extracellular pH (6.8) than at normal tissue extracellular pH (7.4). Therefore, Ox-HPC/CMCS hydrogels show promise as tumor targeting drug carriers.

pH-Responsive oxidized hydroxypropyl cellulose/carboxymethyl chitosan hydrogels for targeted drug release

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