The importance of investigating neuroprotective natural products has increased over the years as the scourge of neurodegenerative diseases (NDs) is on the rise. The ubiquity of limonoids among citrus fruits as well as their promising activity against neurodegenerative processes, namely glutamate toxicity, makes them preferred candidates to develop into lead molecules for the treatment of some types of neurodegenerative diseases. Previous research established the neuroprotective activity of a subset of limonoids derived from traditional medicines, namely limonin, obacunone, calodendrolide, and fraxinellone. In the Martin lab, several analogs of these limonoids have been synthesized and their biological activity is being tested. New insights into their potency and mechanism of action will be discussed.

Synthesis of neuroprotective limonoids and analogs

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