Bioinspired macromolecules can be prepared by bio-conjugation or the use of de-novo biopolymer substitutes. Molecular complexes that are inspired by biological enzyme-substrate interactions can be mimicked with the lock-and-key templating process. The use of functional monomers that can be electrochemically polymerized enables the formation of cross-linked polymer films with cavities that enable high binding assays of analytes: chemical and biological. In this talk, we will show the effective and bio-inspired artificial enzymes for the detection of chemical and biological analytes. Will focus on the demonstration of electropolymerized molecularly imprinted polymer (E-MIP) sensor elements and their ability to utilize transduction methods such as surface plasmon resonance (SPR) spectroscopy oto enable high sensitivity and selectivity. The monomer and molecular design for optimized analyte interaction enable effective templating protocols in a conducting polymer matrix with tunable oxidative states to enable a high volume of analyte-cavity sites. Optimized electropolymerization methods are are important for film deposition and surface characterization. This is demonstrated in the detection of dengue-expressed proteins and drug analytes.

Electrochemically molecularly imprinted polymers (E-MIPS): artificial enzymes or bio-sensors

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ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.