The green synthesis of chalcone derivatives presents an alternate and safer method to synthesize chalcones for analyzing the biological activity. In previous experiments, chalcones contained too many impurities to examine any of the antifungal or antimicrobial properties. This experiment uses two methods of Claisen-Schmidt synthesis to create chalcones by mixing acetophenone and benzaldehyde derivatives in a solvent-free system. The second method involves using zinc nanoparticles, 3-formyl benzopyran-4-one, and acetophenone into a mixture. The zinc nanoparticles in Claisen-Schmidt synthesis should reduce the impurities in the final product. Both methods are solvent-free which avoids possible human risk, environmental harm, and toxicity. Once the chalcones and verified for the expected chemical structure these will be tested for their biological activity; specifically, their ability to inhibit the growth of bacterial and fungal organisms.

Green synthesis of biologically active chalcones using Claisen-Schmidt and zinc nanoparticles

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