Injectable functional biomaterials have made significant progress in cardiac regenerative. In addition, how to adjust the abominable infarction microenvironment and introduce therapeutic stem cells to improve the healing effect become a hotspot. Herein, series antioxidant hydrogels are prepared by combining natural alginate hydrogel with functional nanoparticles including melanin nanoparticles and Au@Pt nanoparticles, et al. Functional nanoparticles with both antioxidative and conductive properties could effectively eliminate reactive oxygen species, enhance the frequency of action potential release of cardiomyocytes, and further reduce the inflammatory factors of macrophage <i>in vitro</i>. The antioxidant, anti-inflammatory and heart electrical integration effects of the hydrogel are investigated <i>in vivo</i>. We found that the macrophage polarization to regenerative M2 macrophages can be greatly promoted in the presence of MNPs/Alg hydrogel (Figure1). The Au@Pt/Alg hydrogel can effectively maintain the paracrine efficiency, pro-angiogenesis effects of BASCs in the infarcted area. These study opens up the recognization of the great value of antioxidant hydrogel for their ability to actively regulate the microenvironment for MI treatment.

Repair of myocardial infarction based on series antioxidant hydrogels

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