Understanding the structure of protein is very important in life science. Amphiphilic copolymers have facilitated this study. For instance, styrene-Maleic anhydride copolymers are well known for facilitating lipid discs formation to provide a native like environment. Amphiphilic behavior of copolymer is the key to the development of this system. The absorption of UV light in styrene ring at 280nm is observed in this system, whereas protein also absorbs at this wavelength. Replacing hydrophobic styrene ring in copolymer can be the possible solution to this problem. In this study, Styrene was replaced with butyl vinyl ether and kinetics of polymerization were investigated. In the effort to understand copolymerization in detail, homopolymerization of butyl vinyl ether (BVE) and maleic anhydride (MAn) was studied using reversible addition−fragmentation chain-transfer (RAFT) technique. Results shown that neither BVE nor MAn goes under homopolymerization. However, both monomers were subjected to go under copolymerization using (RAFT) under previous conditions. NMR conversion results and GPC data show that both monomers undergo copolymerization. To investigate the copolymerization of butyl vinyl ether and maleic anhydride (BVEMA) a kinetic study was performed. It was observed that changing mole ratios of BVE and MAn affects the weight averages of polymers, dispersity and average time. A series of reactions were performed changing mole ratios of polymers from 100% to 0% with respect to each other. It was observed that 66:50 ratio for BVE:MAn can provide maximum conversion of both monomers. The kinetic study of this optimized ratio was compared with the other ratios to understand the pattern of incorporation of both monomers. The effect of the chain transfer agent on optimized ratio was also studied to better understand this system.

Kinetic study of butyl vinyl ether and maleic anhydride copolymerization

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