Due to the escalating cost and scarcity of precious metals commonly used in transition metal-catalyzed reactions, there has been an increasing focus on finding non-precious alternatives. The Center of Catalysis within AbbVie has made strides toward this goal, which will be highlighted in this presentation. In combination with academic collaborations, our group has identified a Cu-catalyzed C-N coupling of sterically hindered coupling partners. Additionally, a Ni-catalyzed Suzuki coupling of Lewis basic substrates featuring a cheap and commercially available ligand will be presented. The substrate scopes and unique mechanistic characteristics of each of these non-precious metal-catalyzed transformations will be discussed.

Development of non-precious metal-catalyzed transformations in process chemistry

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ACS Spring 2023

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