Multicomponent reactions (MCRs) are special types of organic reactions, where three or more reactants react to give a final product in a one-pot procedure. The pharmaceutical industry has a great interest in MCRs because of the growing need to assemble libraries of structurally complex substances for evaluation as lead compounds in drug discovery and development programs. Thiophene fused pyridine systems are one important class of heterocyclic compounds. They attract considerable interest because of their various biological activities. Thienopyridines, which are a class of drug targeting the platelet adenosine diphosphate (ADP) 2-receptor, demonstrate the high importance of this class of compounds. In our research, a multi-component reaction was explored by reacting an aldehyde with malononitrile and NaSH in the presence of a base<sub> </sub>producing a very important intermediate 2-amino-3,5-dicyano-6-mercaptopyridine. This intermediate is the precursor for synthesis of the final product thiophene fused pyridines and other derivatives. It was then undergone alkylation and cyclization reactions after treatment with alpha-halogen compounds in presence of sodium methoxide. All the products were characterized by NMR, IR or MS spectroscopy.

Multicomponent reaction for the synthesis of thiophene fused pyridine heterocycles and other derivatives

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