Harmful algal blooms (HABs) tend to be occurring in increasing frequency and severity across the globe due to changing climate and anthropogenic pollution. From existing literature, HABs are known to yield several classes of toxins; however, out of these classes, microcystins (MCs) are the most frequently studied due to its high toxicity (LD<sub>50</sub>) reported in the range of 50 μg/kg. MC molecule consists of an ADDA group and multiple amino acids; change in amino acids in two locations allows MC to exist in multiple forms such as MC-LR, MC-YR, MC-RR, etc. This work used Alanine, Leucine, and Arginine as molecular templates for sensing, specifically MC-LR. Silica particles were fabricated using carbon dots, TEOS, AEAPMS, and NH<sub>3</sub>. Particles were characterized via several surface characterization methods such as FTIR, TGA, XRD, SEM, and DLS. The fabricated particles were then utilized in fluorescence spectroscopy to assess and evaluate the sensing capability of MCLR in surface water for different amino acid imprinted particles. Lastly, adsorption and desorption isotherms were produced using ELISA-based techniques to evaluate further the binding capacities of MCLR related to different imprinted particles.

Assessment and evaluation of carbon dots embedded silica particle based molecularly imprinted amino acids towards detection of MCLR in surface water via fluorescent based techniques

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