A highly selective palladium-catalyzed hydroborylativ intermolecular coupling of allenes to afford highly substituted 1,3-diene has been established. This coupling reaction has shown high chemo- and stereoselectivity. Phenyl allene, and amidoallene afforded stereoisomeric and chemoisomeric products, respectively. Mechanistic study, ligand screening, and single-crystal structure explained the chemo-, stereoselectivity issues. All the products were isolated and fully characterized in moderate to high yield. The synthetic potential of the products as platform molecules for Diels–Alder reaction derivatives has also been demonstrated.

Catalytic hydroborylative coupling of allenes for chemo-, regio- and stereoselective synthesis of tetrasubstituted 1,3-diene compounds

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.