Complex carbohydrates, “essential molecules of life”, play important roles in many biological processes and are found in many natural products and drugs. But there is little understanding of the mechanisms of these molecules because they are particularly difficult to obtain from natural sources, especially in homogeneous form. Therefore, chemical synthesis is an important tool to gain access to these compounds. However, these syntheses can take months or years because of many challenges in stereoselectivity, regioselectivity, and purification. Despite the recent advances in oligosaccharide synthesis, there is still need for more efficient glycosylation methods in term of yield and selectivity. This work is conducted to develop a new method to achieve highly stereoselective glycosylation products by applying dynamic kinetic resolution. And hopefully, this method would help in the synthesis and creating of different carbohydrate analogues which have biological and pharmaceutical applications in clinical research and study.

Stereoselective glycosylation via dynamic kinetic resolution

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