Diazirine (DAZ)-based photo-crosslinked hydrogels are promising because diazirines can react by biologically safe long wavelength of UV at 350-360 nm, which significantly minimize the photo damage of cells. Diazirines are stable in both acid and base, making it an important tool for photo-affinity labeling (PAL). In this study, 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzene was successfully conjugated to alginate (AL) back bone. This newly synthesized AL-DAZ showed strong shear thinning, and rapid gelation with amine-terminated 8-arm PEG or dendritic polyimine by photo irradiation. Moreover, AL-DAZ showed stronger adhesiveness to porcine skin than fibrin glue. AL-DAZ is expected as new photo-reactive tissue adhesive in future.

Development of photo-cross linkable diazirine-modified alginate for injectable tissue-adhesive

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