Lipid bicellar mixtures can be robustly made of long- and short-chain lipids (or detergents). Hypothetically, the final structure mainly depends on the properties of the long-chain lipid and the short-chain lipid (or detergent) only serves as an edge-stabilizer to minimize the line tension. Here, we investigate the effects of short-chain lipids or detergents, e.g., dihexanoyl phosphatidylcholine (DHPC), Triton X-100, sodium dodecyl sulfate (SDS), and 3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate (CHAPSO) on the morphology individually. The long-chain lipid remains dipalmitoyl phosphatidylcholine (DPPC). Intriguingly, even the detergent-like molecules can play an important role in the final morphology according to their charge density, molecular architectures, miscibility with DPPC, and melting transition temperatures. This study provides insight into the formation mechanism of discoidal micelles, ribbons, lamellae, and vesicles, allowing scientists to design lipid self-assemblies rationally in a controllable manner.

Influence of shor-chain lipid (detergent-like molecules) on the morphology of bicelles

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