This study evaluated the use of HSA nanoparticles for delivery of near-infrared ionic dye (IR 780) and rhodamine 6G chemotherapeutic drug for theranostics against cancer. Rhodamine 6G has selective tumor toxicity whereas IR 780 is a near-infrared (NIR) dye with photothermal effect upon NIR laser irradiation. The HSA nanoparticles synthesized with a size of 150 nm were have potential for effective treatment of tumors from the synergistic chemotherapeutic and photothermal effect. This study reports the encapsulation efficiency and the release of these therapeutic agents from HSA nanoparticles by the enzymatic action of metalloproteinases that are overexpressed in tumor cells and by photothermal heating under laser irradiation.

Multifunctional human serum albumin nanoparticles with indocyanine green and rhodamine 6G ionic chemotherapeutic agent for theranostics

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.