<br/>The calcified deposits that accumulate in the aging eye and brain are a hallmark of diseases of aging, including age-related macular degeneration and Alzheimer's disease, and share similarities with the plaques that form in atherosclerosis. These deposits are rich in blood proteins, lipids and hydroxyapatite, the stable, mineralized form of hydroxylated calcium phosphate that makes up the bulk of bone and teeth, but the process of deposit formation is poorly understood. Using NMR experiments with both soluble and solid-state samples, we explore how proteins associate with calcium, hydroxyapatite and lipids to form these complex molecular assemblies. NMR experiments provide structural and functional information, with atomic-level resolution, about the molecular constituents of these heterogeneous aggregates, in samples that resemble the native environment as closely as possible.

NMR structural studies of protein-lipid assemblies

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