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ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Current Topics in Biological Chemisry

Identification of active site residues that control nucleotide-sugar selection in nucleocytoplasmic O-glycosyltransferases

Stimulus-responsive proteins with imine/enamine phosphonium linkages formed through ionic liquid-based bioconjugation

Cell-specific delivery of isoprenoid precursors in mammalian cells

Understanding protein-protein interactions in chromosome remodeling with Hip1: The yeast analog of HIRA

Relaxing a catalytic triad in alkaline phosphatase

Characterization of a new polyamine transformation catalyzed by human aldo-keto reductase 1C3

Synthesis of nonulosonic acids from aldolase enzymes naturally occurring in hyperthermophiles

Kinetic analysis of ATP associated in the DEAD-box protein Rok1p

Biomineralizated nano-armor synergistically enhances antitumor activity of neutrophil elastase against lung cancers via inhaled administration

Design and biological evaluation of a chimeric cell-penetrating peptide

Protein-interaction network of cell-wall lytic transglycosylase RlpA of Pseudomonas aeruginosa

Investigating reduction potentials of RNA aptamer-bound flavins

Correlation of the donor−acceptor distances with kinetic isotope effects in hydride tunneling reactions in solution to test the proposed role of protein dynamics in enzyme catalysis

Fluorescent D-amino acid-based approach enabling fast and reliable measure of antibiotic susceptibility in bacterial cells

O-GlcNAcylation on Hsp27 enhances inhibition of the caspase 3 activation to block intrinsic apopotosis pathway

Influence of RpoH and RpoF overexpression on quinolone, macrolide, and glycopeptide antibiotic tolerance and biofilm growth in E. coli

In-silico study of designed eutectic mixtures of active pharmaceutical ingredients with improved aqueous solubility

High-performance bioplastics from single-carbon feedstocks

Small molecule immunomodulation of autoimmune disorders

Tumor-associated antigen surface density in mechanisms of CAR T cell activation threshold-setting

Development of detergent-free methods of membrane protein reconstitution into the lipidic cubic phase

Screening catalog design for machine learning prediction applied to 2-Oxoglutate dependent enzymes

Functionalized biochar for heparin recovery

Comammox nitrospira bacteria are dominant ammonia oxidizers in mainstream nitrification bioreactors emended with sponge carriers

Structural analysis of monoclonal antibody targeting folate receptors

Mutagenesis of L-DOPA dioxygenase to improve activity on non-native substrates

Qualitative analysis and characterization of cyclopropyl fatty acids from plasma

Characterization of a cysteine-selective inhibitor of the bacterial fatty acid synthase enzyme enoyl-ACP reductase using mass spectrometry

Novel quinolines to serve as copper chelators as a potential therapeutic for Alzheimer’s disease

In-silico study on antidiabetic and antioxidant activity of bioactive compounds in Ficus carica L

Light controlled reversible Michael addition of cysteine: A new tool for dynamic site-specific labeling of proteins

Heparin uptake by using silica-based materials

Investigation of the interactions between Rev1 and DHX36 during replication of G-quadruplex DNA

Studying GFP production in E. coli for a more direct correlation to RNA thermometer behavior

Topoisomerase and thiosemicarbazone binding affinity analysis

Spatial and chemical reprogramming of neutral lipids in hypoxia-resistant cancer cells

Structure and reactivity of BpHMGR and its cofactor specificity

Cellular investigation of UHRF1 interactions with a novel histone modification

Determination of ligand interactions for 12α-hydroxysteroid dehydrogenase: Critical enzyme in catabolic pathway of bile acids

Global cellular metabolic rewiring adapts Corynebacterium glutamicum to efficient non-natural xylose utilization

Exploring biophysical characteristics and catalytic activity of human carbonic anhydrase

Cell catalysis of citrate to itaconate by engineered Halomonas bluephagenesis

D-RNA selects L-amino acids in a newly characterized aminoacyl-RNA loop ligation

In-vivo inhibition of isopentenyl pyrophosphate isomerase

Influence of overexpression of the phosphodiesterase YhjH on E. coli biofilm formation and composition

Role of PEGylated gold nanoparticles on insulin fibrillation

Transforming Lactobacillus plantarum with a luc-containing plasmid to evaluate the induction of quorum sensing through bioassays via luciferase production

Blockading the sialoglycan-siglec immune checkpoint axis for cancer immunotherapy

Investigating the effects of variants of unknown significance on the binding interaction between BRCA1 and PALB2 for breast cancer predisposition

Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity

Purification and antibiotic inhibition of L,d transpeptidase in Enterobacter cloacae

Isolation of unique retroelements in genomic DNA of Procambarus clarkii

Synthetic strategies and methodologies of alkyl phenols derivatives for biological activities

LrhA transcriptional regulator differentially modulates gamma-keto-N-acyl amide GPCR agonists in Xenorhabdus nematophila

Correlating blue light responses of Pseudomonas aeruginosa to pyocyanin production

Competitive influence of alkali metals in the ion atmosphere on nucleic acid duplex stability

Experimental and computational analysis of physiological reactions with human axial sweat

Discovery of sequence fingerprints governing substrate specificity in a microbial oxidoreductase

Defining and modulating quorum sensing in Lactobacillus plantarum

The interactions between HNRNP K mRNA and miR-1249-3P are mediated by a noncanonical G quadruplex structure

Tyrosine hydroxylase in dopaminergic neuron cells leads to increased oxidative stress and cell death by activation of acidosis

Integrated analysis of the transcriptome and metabolome reveals genes involved in terpenoid and flavonoid biosynthesis in Gynostemma pentaphyllum (Thunb.) Makino

Synthesis and characterization of pyridinium-based D-amino acid fluorescent molecular rotors

Iron regulation with glutathione and ferritin in the labile iron pool

Effect of peptide sequence order on pleated and rippled β-sheet assembly of isomeric amphipathic peptides

Optimized and expedited synthesis of Janelia Fluor® rhodamine based dyes

Determining enzyme kinetic rate constants to predict viral enzyme mutations

Cataloging novel quorum sensing genes

Discovery of virulence-disarming inhibitors for two-component systems in bacteria

Interrogation of small molecules to surface-bound aptamer binding kinetics with electrochemical, aptamer-based sensors using intermittent pulse amperometry

Dissolution of bispecific antibody aggregates via improved UFDF and formulation strategy

Identification and evaluation of lead compounds to inhibit methicilin resistant Staphylococcus aureus (MRSA) biofilms

Process intensification for robust downstream processing of antibody fragments

Integrating computational and experimental chemistry: A coupled approach to establishing an in silico antibiotic efficacy prediction model

Changes in tolerance of amphenicol and tetracycline antibiotics with stress-responsive transcription factor overexpression in E. coli

Apolipoprotein E variants contribute to metabolomic changes of neuroplasticity proteins commonly associated with Alzheimer’s disease

Sensing dielectric relaxation in thermal unfolding of lipase

Gene expression profile reveals breast cancer proliferation and metastasis

Y2 Thoeris immunity against bacteriophages: Discovery of chemical inhibitors

Effects of phospholipid liposomes on prion peptide (106-128) amyloidogenesis

Beta-lactamase suppression to treat methicillin-resistant Staphylococcus aureus infections

Structural characterization of protein arginine deiminase 2 interaction with histone H3 N-terminus

Identifying novel 3H- pyrazolo[4,3-f]quinoline-based CLK1/2 inhibitors in renal cancer therapeutics

Metabolic incorporation of cell permeantisopentenyl and dimethylallyl pyrophosphate in bacteria

Depolymerization method and research progress of lignins

Antimicrobial activity of the ethanolic and aqueous extract of passion fruit (Passiflora edulis), in the absence and presence of transition metal salt: Zn(OAC)2.2H2O

Comparative docking approaches to identify conformationally selective ligands

Site-specific DNA modification by urea-forming amine-azide coupling

Characterization of modified Bacillus subtilis strains to investigate translesion synthesis

Phytochemical analysis of plant extracts and their antimicrobial properties against pathogenic bacteria

Characterization of the protein WP_002719569.1 from Cereibacter sphaeroides

Uncovering the chemistry that drives symbiosis: A case study of the interactions between Capsaspora owczarzaki and Biomphalaria glabrata as a potential agent against Schistosomiasis

Comparative study of 5- fluorouracil, doxorubicin, methotrexate, paclitaxel for their inhibition ability for Mpro of nCoV: Molecular docking and molecular dynamics simulations

Bioorthogonal chemical reporter for profiling the lactylome

Development and characterization of novel ATP analogs for studying protein phosphorylation and kinase enzymes

Finding drug targets for control of persisters in MRSA biofilm

Comparison of two human gut microbiome-derived drug-metabolizing dehydrogenases

Synthesis and analysis of GlcNAc modified Hsp27 and its effects on CMT2

Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

Elucidating the roles of the transcriptional regulator Mce3R in Mycobacterium tuberculosis drug resistance

Current Topics in Biological Chemisry

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Identification of active site residues that control nucleotide-sugar selection in nucleocytoplasmic O-glycosyltransferases