**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
Aina Gayà-Barroso 1,2, Juan González-Moreno 1,2, Adrián Rodríguez 1,2, Tomás Ripoll-Vera 2,3, Inés Losada López 1,2, Milena Paneque 4,5,6, and Eugenia Cisneros-Barroso 1,2,
1. Internal Medicine Department. Son Llàtzer University Hospital. Palma de Mallorca. Spain.
2. Health Research Institute of the Balearic Islands (IdISBa), Son Llàtzer University Hospital, Palma de Mallorca, Spain.
3. Cardiology Department. Son Llàtzer University Hospital. Palma de Mallorca. Spain.
4. Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.
5. Center for Predictive and Preventive Genetics, Institute for Molecular and Cell Biology (CGPP-IBMC), Porto, Portugal.
6. Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.

**Main Body of the Abstract**
Background:
Variant transthyretin amyloidosis (ATTRv) is a rare genetic disease that affects patients' quality of life by affecting various organs and tissues. Despite a wealth of research on medical and psychosocial interventions, the impact of occupational therapy on patients with ATTRv is not well understood. This research focuses on the assessment of activities of daily living and occupations as a fundamental tool in the management of patients after diagnosis.
Objective:
The aim of this study was to develop an occupational therapy programme for the improvement of daily functioning and quality of life in patients with ATTRv.
Methods:
After an initial semi-structured interview, fourteen patients with ATTRv were enrolled in the study. The occupational therapist worked with the patient to develop short and medium term occupational goals, based on the Model of Human Occupation. During the six-month intervention period, weekly or ten-day sessions were held to monitor and adjust the guidelines. Outcomes were measured using scores for activities of daily living and psychological well-being.
Results:
The results showed that twelve patients stayed the same in their activities of daily living, two got worse and eight improved their psychological scores and the occupational situation. The study highlights the importance of early intervention and further research into the effectiveness of occupational therapy  interventions for patients with ATTRv. It also notes that patients who received occupational therapy intervention reported that six months was not enough and emphasises the fundamental role of the therapist in providing motivation, facilitating meaningful activities, improving daily living and routines.



**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
**Aina Gayà-Barroso 1,2, Juan González-Moreno 1,2, Adrián Rodríguez 1,2, Tomás Ripoll-Vera 2,3, Inés Losada López 1,2, Milena Paneque 4,5,6, and Eugenia Cisneros-Barroso 1,2,**
1. Internal Medicine Department. Son Llàtzer University Hospital. Palma de Mallorca. Spain.
2. Health Research Institute of the Balearic Islands (IdISBa), Son Llàtzer University Hospital, Palma de Mallorca, Spain.
3. Cardiology Department. Son Llàtzer University Hospital. Palma de Mallorca. Spain.
4. Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.
5. Center for Predictive and Preventive Genetics, Institute for Molecular and Cell Biology (CGPP-IBMC), Porto, Portugal.
6. Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.

**Main Body of the Abstract**
**Background:**
Variant transthyretin amyloidosis (ATTRv) is a rare genetic disease that affects patients' quality of life by affecting various organs and tissues. Despite a wealth of research on medical and psychosocial interventions, the impact of occupational therapy on patients with ATTRv is not well understood. This research focuses on the assessment of activities of daily living and occupations as a fundamental tool in the management of patients after diagnosis.
**Objective:**
The aim of this study was to develop an occupational therapy programme for the improvement of daily functioning and quality of life in patients with ATTRv.
**Methods:**
After an initial semi-structured interview, fourteen patients with ATTRv were enrolled in the study. The occupational therapist worked with the patient to develop short and medium term occupational goals, based on the Model of Human Occupation. During the six-month intervention period, weekly or ten-day sessions were held to monitor and adjust the guidelines. Outcomes were measured using scores for activities of daily living and psychological well-being.
**Results:**
The results showed that twelve patients stayed the same in their activities of daily living, two got worse and eight improved their psychological scores and the occupational situation. The study highlights the importance of early intervention and further research into the effectiveness of occupational therapy  interventions for patients with ATTRv. It also notes that patients who received occupational therapy intervention reported that six months was not enough and emphasises the fundamental role of the therapist in providing motivation, facilitating meaningful activities, improving daily living and routines.



Daily life in patients with hereditary transthyretin amyloidosis: a qualitative study. PC29 (#1)

We invite you to attend the XIX International Symposium on Amyloidosis to be held in Rochester, MN.

This symposium is organized as a hybrid meeting (with the focus on in-person) held from Sunday, May 26 through Thursday, May 30, 2024.

Together with the ISA Board and members of Mayo Clinic, a very attractive scientific hybrid program is being planned. The program will cover a variety of types of systemic amyloidosis: ATTR (hereditary and wild-type), AL (light-chain), AA and less frequent forms. There will be key lectures, specific symposia including those company sponsored, oral presentations and poster sessions of accepted abstracts.

COURSE DESCRIPTION
This program will provide a comprehensive review of state-of-the-art education in systemic amyloidosis: basic science, pathophysiology, diagnosis, current and emerging treatments. Scientific presentations will include competitive oral and poster abstracts. The rapid evolution of scientific discovery and expanding treatment options has created tremendous interest in the field and this meeting will fill and important gap in educating scientists and clinicians.