**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
Amira zaroui : 1. AP-HP (Assistance Publique-Hôpitaux de Paris), Cardiology Department, DMU care, Henri Mondor University Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, F-94010, Créteil, France
2. AP-HP (Assistance Publique-Hôpitaux de Paris), Cardiac Amyloidosis Referral Centre, Cardiogen Network, Henri Mondor University Hospital, 51 Avenue du Marechal de Lattre de Tassigny, F-94010, Créteil, France
3. Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health
Charlotte Lafont : 1. AP-HP (Assistance Publique-Hôpitaux de Paris), Cardiology Department, DMU care, Henri Mondor University Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, F-94010, Créteil, France
2; Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health
AP-HP (Assistance Publique-Hôpitaux de Paris), Public Health Department, Henri Mondor University Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, F-94010, Créteil, France

**Main Body of the Abstract**
Background and Aims:Wild-type transthyretin cardiac amyloidosis (ATTRwt-CM) is diagnosed with increasing frequency and  become more prevalent with age.The objective of the present study was to examine the change in prevalence of ATTRwt-CM among women and to evaluate baseline characteristics, clinical course, cardiac and extracardiac phenotypes, and prognosis as a function of sex and age.Methode retrospective study of  ATTRwt-CM patients  . Comparaison between Women and men overall for phenotype and identification of interaction between age of diagnostic and prognostic between sex , Utilisation mailtiple regression by strate of age to identifie heterogeneaous phenotype by sex.Results:1062 patients with ATTRwt-CM,  180 women (16%) had a higher left ventricular ejection fraction (LVEF) , lower interventricular septum thickness and posterior wall at end diastoleeven after adjustment for body size and surface area. Troponin levels were higher in women  . Quartiles of age  were Q1 ≤77, Q2 78 -82, Q3, 83 - 86, and Q4 >86. Compared men , women in Q1 had a lower LVEF and GLS .Logistic regression analysis by age class showed that these probabilities fell with age . women had a greater risk of sudden death  (13.8% vs. 4.6%, respectively; OR [95%CI]=3.24 1.56-6.64; p=0.001) . Tafamidis reatment was associated with better survival in men HR [95%CI] = 0.61 [0.39-0.95] .Conclusions Women with ATTRwt-CM are less frequently diagnosed than men with ATTRwt-CM and are diagnosed at a later age. In contrast to the outcomes for men, the mortality rate is higher among young women with ATTRwt-CM  than among older women with ATTRwt-CM .



**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
Amira zaroui : 1. AP-HP (Assistance Publique-Hôpitaux de Paris), Cardiology Department, DMU care, Henri Mondor University Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, F-94010, Créteil, France
2. AP-HP (Assistance Publique-Hôpitaux de Paris), Cardiac Amyloidosis Referral Centre, Cardiogen Network, Henri Mondor University Hospital, 51 Avenue du Marechal de Lattre de Tassigny, F-94010, Créteil, France
3. Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health
Charlotte Lafont : 1. AP-HP (Assistance Publique-Hôpitaux de Paris), Cardiology Department, DMU care, Henri Mondor University Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, F-94010, Créteil, France
2; Clinical Epidemiology and Ageing (CEpiA) Geriatrics, Primary Care and Public Health
AP-HP (Assistance Publique-Hôpitaux de Paris), Public Health Department, Henri Mondor University Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, F-94010, Créteil, France

**Main Body of the Abstract**
**Background and Aims:**Wild-type transthyretin cardiac amyloidosis (ATTRwt-CM) is diagnosed with increasing frequency and  become more prevalent with age.The objective of the present study was to examine the change in prevalence of ATTRwt-CM among women and to evaluate baseline characteristics, clinical course, cardiac and extracardiac phenotypes, and prognosis as a function of sex and age.**Methode** retrospective study of  ATTRwt-CM patients  . Comparaison between Women and men overall for phenotype and identification of interaction between age of diagnostic and prognostic between sex , Utilisation mailtiple regression by strate of age to identifie heterogeneaous phenotype by sex.**Results:**1062 patients with ATTRwt-CM,  180 women (16%) had a higher left ventricular ejection fraction (LVEF) , lower interventricular septum thickness and posterior wall at end diastoleeven after adjustment for body size and surface area. Troponin levels were higher in women  . Quartiles of age  were Q1 ≤77, Q2 78 -82, Q3, 83 - 86, and Q4 >86. Compared men , women in Q1 had a lower LVEF and GLS .Logistic regression analysis by age class showed that these probabilities fell with age . women had a greater risk of sudden death  (13.8% vs. 4.6%, respectively; OR [95%CI]=3.24 1.56-6.64; p=0.001) . Tafamidis reatment was associated with better survival in men HR [95%CI] = 0.61 [0.39-0.95] .**Conclusions** Women with ATTRwt-CM are less frequently diagnosed than men with ATTRwt-CM and are diagnosed at a later age. In contrast to the outcomes for men, the mortality rate is higher among young women with ATTRwt-CM  than among older women with ATTRwt-CM .



Wild-type transthyretin cardiac amyloidosis: sex differences in prevalence, cardiac and extracardiac phenotypes, and prognosis PB61 (#126)

We invite you to attend the XIX International Symposium on Amyloidosis to be held in Rochester, MN.

This symposium is organized as a hybrid meeting (with the focus on in-person) held from Sunday, May 26 through Thursday, May 30, 2024.

Together with the ISA Board and members of Mayo Clinic, a very attractive scientific hybrid program is being planned. The program will cover a variety of types of systemic amyloidosis: ATTR (hereditary and wild-type), AL (light-chain), AA and less frequent forms. There will be key lectures, specific symposia including those company sponsored, oral presentations and poster sessions of accepted abstracts.

COURSE DESCRIPTION
This program will provide a comprehensive review of state-of-the-art education in systemic amyloidosis: basic science, pathophysiology, diagnosis, current and emerging treatments. Scientific presentations will include competitive oral and poster abstracts. The rapid evolution of scientific discovery and expanding treatment options has created tremendous interest in the field and this meeting will fill and important gap in educating scientists and clinicians.