**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
Frederic Rousseau, Switch Laboratory, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium

**Main Body of the Abstract**
There are currently a few hundred cryoEM structures at atomic resolution of patient-derived and lab-generated amyloid fibrils, a situation comparable to where the field of globular protein structure was in the mid-1980s, at which time the first rules of protein architecture were being drawn up. We have employed a combination of computational and biophysical techniques to start analyzing the way in amyloids structures are stabilized and we propose a model of framework polymorphism: where aggregation prone regions (APRs) in the amyloid core stabilize act as anchor points on which the rest of the structure is suspended. Amyloid structures can assemble into different arrangements of the APRs, called polymorphs, and these have similar free energies. As a result of this, slight changes in the conditions, or heterotypic interactors can affect the polymorphs formed. This model may help explain key features of amyloid deposition pathologies.



What the structures of amyloids teach us about amyloid pathology OB16 (#339)

We invite you to attend the XIX International Symposium on Amyloidosis to be held in Rochester, MN.

This symposium is organized as a hybrid meeting (with the focus on in-person) held from Sunday, May 26 through Thursday, May 30, 2024.

Together with the ISA Board and members of Mayo Clinic, a very attractive scientific hybrid program is being planned. The program will cover a variety of types of systemic amyloidosis: ATTR (hereditary and wild-type), AL (light-chain), AA and less frequent forms. There will be key lectures, specific symposia including those company sponsored, oral presentations and poster sessions of accepted abstracts.

COURSE DESCRIPTION
This program will provide a comprehensive review of state-of-the-art education in systemic amyloidosis: basic science, pathophysiology, diagnosis, current and emerging treatments. Scientific presentations will include competitive oral and poster abstracts. The rapid evolution of scientific discovery and expanding treatment options has created tremendous interest in the field and this meeting will fill and important gap in educating scientists and clinicians.