**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
Name: Anna Paula Paranhos Miranda Covaleski 
Institution: Hospital das Clínicas da Universidade Federal de Pernambuco 
City: Recife 
State: Pernambuco - Brazil

**Main Body of the Abstract**
Introduction
The V122I founder appears to have originated in West Africa. The African ancestry is present all over Brazil, more prevalent in the northeast region. The aim of this study is to evaluate the distribution of V122I carriers in Brazil and determine its demographic characteristics. 
Methods
A national, multicenter (10 reference centers), observational, cross-sectional study to evaluate the distribution and demographic characteristics among individuals with V122I mutation in Brazil. 
Results
We found 246 TTR V122I carriers from 84 families: 240 heterozygous, 4 homozygous, and 2 compound heterozygous (V30M/V122I and I107V/V122I). Gender distribution was similar. Age: 19 to 89 years, mean 53.4. Race: 26.7% white, 17.3% black and 56% mixed. Individuals were born in all regions of Brazil, mainly in the states of Pernambuco (32.4%), Bahia (32%), São Paulo (16.4%) and Minas Gerais (8.6%). A greater concentration was found in the cities: Salvador (11%), Recife (8,9%) Uberlândia (4,5%) and in the banks of the São Francisco River. The distribution of state of residence maintained mainly in the same areas. 
Discussion
This study demonstrates the V122I variant, both in whites, black and mixed brazilian individuals and shows endemic areas with a high concentration of this allele on the northeast region of Brazil, which can be explained by a possible common founder effect. The slaves came to Brazil from 2 different regions: West and Central Africa. The endemic areas are associated with the slave route from West Africa. This study allowed a better understanding of the scenario of ATTRV122I Amyloidosis in Brazil.



**Author Listing - Lead/ Submitting Author (we will be communicating with this individual): Name, Institution, City and State where the work was done. Co-authors will be added in a separate section.**
Name: Anna Paula Paranhos Miranda Covaleski 
Institution: Hospital das Clínicas da Universidade Federal de Pernambuco 
City: Recife 
State: Pernambuco - Brazil

**Main Body of the Abstract**
**Introduction**
The V122I founder appears to have originated in West Africa. The African ancestry is present all over Brazil, more prevalent in the northeast region. The aim of this study is to evaluate the distribution of V122I carriers in Brazil and determine its demographic characteristics. 
**Methods**
A national, multicenter (10 reference centers), observational, cross-sectional study to evaluate the distribution and demographic characteristics among individuals with V122I mutation in Brazil. 
**Results**
We found 246 TTR V122I carriers from 84 families: 240 heterozygous, 4 homozygous, and 2 compound heterozygous (V30M/V122I and I107V/V122I). Gender distribution was similar. Age: 19 to 89 years, mean 53.4. Race: 26.7% white, 17.3% black and 56% mixed. Individuals were born in all regions of Brazil, mainly in the states of Pernambuco (32.4%), Bahia (32%), São Paulo (16.4%) and Minas Gerais (8.6%). A greater concentration was found in the cities: Salvador (11%), Recife (8,9%) Uberlândia (4,5%) and in the banks of the São Francisco River. The distribution of state of residence maintained mainly in the same areas. 
**Discussion**
This study demonstrates the V122I variant, both in whites, black and mixed brazilian individuals and shows endemic areas with a high concentration of this allele on the northeast region of Brazil, which can be explained by a possible common founder effect. The slaves came to Brazil from 2 different regions: West and Central Africa. The endemic areas are associated with the slave route from West Africa. This study allowed a better understanding of the scenario of ATTRV122I Amyloidosis in Brazil.



V122I Hereditary Transthyretin Amyloidosis in Brazil: an Endemic Variant PB37 (#340)

We invite you to attend the XIX International Symposium on Amyloidosis to be held in Rochester, MN.

This symposium is organized as a hybrid meeting (with the focus on in-person) held from Sunday, May 26 through Thursday, May 30, 2024.

Together with the ISA Board and members of Mayo Clinic, a very attractive scientific hybrid program is being planned. The program will cover a variety of types of systemic amyloidosis: ATTR (hereditary and wild-type), AL (light-chain), AA and less frequent forms. There will be key lectures, specific symposia including those company sponsored, oral presentations and poster sessions of accepted abstracts.

COURSE DESCRIPTION
This program will provide a comprehensive review of state-of-the-art education in systemic amyloidosis: basic science, pathophysiology, diagnosis, current and emerging treatments. Scientific presentations will include competitive oral and poster abstracts. The rapid evolution of scientific discovery and expanding treatment options has created tremendous interest in the field and this meeting will fill and important gap in educating scientists and clinicians.