Hyperlipidemia, a major risk of cardiovascular disease (CVD), is defined as elevated levels of lipids such as cholesterol and triglycerides. Hyperlipidemia can be prevented and managed through healthy eating and regular exercise. With the increasing prevalence of hyperlipidemia, this study aimed to examine the relationship between predicted hsCRP score and hyperlipidemia among women in the Korea Nurses’ Health Study.
In this prospective cohort study, a total of 6,910 women aged 21-50 years were included from the Korea Nurses’ Health Study (KNHS). The predicted hsCRP score was derived from demographic, lifestyle, dietary, and anthropometric factors. Dietary factors were derived based on a validated food frequency questionnaire (FFQ). Hyperlipidemia was defined as the presence of any one of the following: 1) total cholesterol ≥240 mg/dl, 2) HDL-cholesterol <50 mg/dl, or 3) triacylglycerol ≥200mg/dl. We also considered participants who were diagnosed with hyperlipidemia or current use of hyperlipidemia medication as having hyperlipidemia. Cox proportional hazard regression analysis was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) with adjustment for potential confounding factors.
During a mean follow-up of 5.81 person-years, 1,866 cases of hyperlipidemia were identified. After multivariable adjustment, the RRs (95% CIs) for hyperlipidemia comparing the highest predicted hsCRP score with the lowest predicted hsCRP score were 1.20 (1.02-1.40), 1.13 (0.96-1.32), 1.27 (1.08-1.49), and 1.64 (1.39-1.92), respectively (P for trend < 0.001).
Our results support that increasing predicted hsCRP scores were associated with increased risk of hyperlipidemia. These findings suggest that dietary and lifestyle changes aimed at reducing inflammation may help prevent hyperlipidemia.

OC127 - Association between predicted hsCRP score and hyperlipidemia among women: the Korea Nurses’ Health study

Unique to the new Congress (previously the Summer Conference) is that you will have greater opportunity to engage with more nutrition science than ever before. In 2024 the core programme will be delivered by the Irish Section of The Nutrition Society, supported by the Science Committee. The theme of these symposia will be ‘new data – focused approaches and challenges’. Outside of the core programme you will have the chance to hear the latest research from the Society’s partner organisations, universities, the private sector and more, on a diverse range of research.