253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Biologically-Related Molecules & Processes

Process research and development of the commercial synthesis of BTK inhibitor GDC-0853

Development of a practical synthesis of ERK inhibitor GDC-0994

Novel architectures that exhibit potent and selective inhibition of protein tyrosine phosphatases implicated in cancers and metabolic disease

Development of an expedient synthesis to GDC-0853: A reversible Bruton’s tyrosine kinase inhibitor

Versatile synthesis of chlorin and application in bio-medicine

Exploration of advance synthetic processes for generating heterocyclic scaffolds: Synthetic scope and mechanistic insight

Synthesis of photocyclization/oxidation-based fluorophores for cell and tissue imaging

Investigation and synthesis of isoform-selective histone deacetylase inhibitors

Progress towards an anti-inflammatory based on the aurone scaffold

Fast track process research: Identification and development of highly improved routes to GDC-0810

High-throughput evaluation of small-molecule catalyst libraries: Development of an amphiphilic, DNA-encoded reaction discovery platform

Practical and concise synthesizes of antifungal amphiphilic kanamycin analogs

Discovery chemistry towards BTK inhibitor GDC-0853

Synthesis of oligodeoxynucleotides containing electrophilic groups

Photocaged NAD+ for mechanistic investigations of HMG-CoA reductase

Pd-catalyzed arylation of cyclic and spirocyclic diamines under aerobic conditions

DNA compatible nitro reduction and benzimidazole synthesis

Synthesis of oligonucleotides containing C8-2'-deoxyguanosine adduct of the tobacco carcinogen 2-amino-9H-pyrido [2, 3-b] indole (AαC)

PBr3-mediated unexpected reductive deoxygenation of α-aryl-pyridinemethanols: Synthesis of arylmethylpyridines toward EP1 antagonists

Design, synthesis, and biological evaluation of a benzannulated spiroketal pilot library

Synthesis and biological evaluation of novel heterocyclic scaffolds as infectious disease lead compounds

Epoxyisoindoline formation through tandem Ugi-Smiles Diels-Alder reactions

Zwitterionic pyrrolidine-phosphonates: Transition state mimics of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S

Development of a tandem oxy-Michael Ugi-Smiles reaction

Chemosynthetic livers: Predict, prepare and prove the structure, activity and toxicity of drug metabolites

Fluorescent derivatives of arachidonic acid: Tools for studying the anti-cancer activity of prostaglandins

Origin of RNA: Model studies for the prebiotic synthesis of nucleosides

Co-bisintercalating FRET-based fluorescent bottlebrush polymer nanotags

Synthesis of functionalized oligonucleotides of RNA using 2-methylbenzothiophenyl groups at the C2’-O- position of uridine and adenosine

Synthetic and metabolic studies of deuterium labeled drugs

Computational modeling of PikC activity and selectivity for guided protein and substrate engineering

Exploring vinylboronic acids as reactants in bioorthogonal chemistry

Designing foldamers: Synthesis of hydrophilic peptoids that fold in a predictable manner

Chemosynthetic livers: Evaluating plausible drug-drug interactions relating to metabolite suppression or attenuation

Leveraging biosynthetic enzymes for complex molecule synthesis

Strain induced couplings mediated by visible light

Azaaurones: An unexplored scaffold for biological activity

Chemical synthesis of the potent anticancer agent prunustatin A

Reversibly photoactivatable Janelia Fluor dyes, and their utility in imaging cellular features beyond the diffraction limit

Design of a novel fluorescent sensor for chloride

Synthesis and analysis of propargylglycine-based derivatives as potential inhibitors of LpxC

Synthesis and applications of photoactive analogues of isoprenoid diphosphates incorporating diazirines

Synthesis of menaquinone (MK) analogs and investigation into the solution structure of MK-1 and MK-1 (H2)

Synthesis of β-APN derivatives for inhibition of the LOX enzyme

Comparative in vitro translation control using antisense γPNA

Synthesis and evaluation of dye derivatives as G-quadruplex-stabilizing molecules

Construction of a new eighteen-membered core structure for simplified and stabilized zampanolide mimics

Synthesis and characterization of dyes for use in biological zinc-ion and reactive oxygen species dual imaging

Fluorescent probes for imaging potassium in living cells

Fluorogenic dyes for haloalkane-based protein labeling in vitro and in bacterial cells

Imaging with novel catecholamine-selective fluorescent sensors

Schiff bases and hemiaminals: Synthesis, mechanism of formation and biological evaluation

Rational design and facile synthesis of highly modular turn-on fluorescent probe

Development of synthetic methods for the preparation of biologically active compounds

Synthesis and atropisomeric binding of novel β-carbolines to brain receptors

Hydrophilized cell-permeant dyes with secondary alcohol functionalities for live cell STED imaging

Environment activable nanoprodrug: Two-step surveillance in the anticancer drug release

5-Azido-modified pyrimidine nucleosides: Chemistry and biology

Rearrangement chemistry of aryl and heteroaryl sulfonamides

Peridinin is a potent probe for the role of bilayer lipid peroxidation in pathogenesis

Design and synthesis of halogen bonding compounds for the inhibition of IGPs

Increasing the therapeutic index for head-and-neck squamous cell carcinoma targeted therapy through the derivatization of deoxynyboquinone

Water-soluble NIR-absorbing rylene chromophores for biomedical applications

Development of amino acid-based inhibitors against Aspartate-N-Acetyltransferase (ANAT) for the treatment of Canavan disease

Towards understanding of peroxidation of mammalian sterols: Microwave-assisted synthesis of 7-dehydrocholesterol isomers

Synthesis and implementation of oxetane-based chemical probes to study polyketide biosynthesis

Expedient and modular access to [6,5]- and [6,6]-2-azabicyclic morpholinones by iron- or palladium-catalyzed intramolecular coupling of vicinally functionalized alcohol-bearing allylic lactams

Synthesis and biological evaluation of inhibitors of KasA indentified through virtual screening: A novel inhibitor of Mycobacterium tuberculosis

Cleavable fluorescent probes for direct measurement of nutrient uptake

Fluorescent probes for targeting fructose transport

Privileged diversity oriented organic synthesis: Modular one-step route for the synthesis of novel compound collections for phynotypic screening

Efficient cross metathesis of allyl sulfones with isoprenoids for the synthesis of fluorescent lipid probes

Structural modifications of OXE receptor antagonists towards improved in vivo metabolic stability

Synthesis, chemical reactivity, and medicinal activity of novel chiral piperidines

Di-substituted maleamic acid as an ultra acid-sensitive, cleavable linker for reversing the cytotoxicity pH-profile of doxorubicin in small molecule prodrugs

Synthesis of 6-substituted dopamine derivatives

Selective functionalisation and diversification of halogenated compounds through mild aqueous cross-coupling methodologies: From organic molecules to natural products

Synthesis of gyramide-bound photoaffinity reagents for DNA gyrase

Molecular approaches to photocontrol of biological singlet dioxygen

Shake it off: Ring expanded sugars as ligands for the E. coli lectin FimH

Time-resolved mechanism of SpnF-catalyzed Diels-Alder reaction

Synthesis and characterization of a verdazyl radical labeled amino acid spin probe

Targeting infectious diseases with dihydropyrimidinone-derived chemotypes

Fluorescent probes for imaging formaldehyde in living cells

Aurones: Synthesis and a template for biological investigations

Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone

Tandem incorporation of enantiomeric residues engenders discrete peptoid structures

Design, synthesis and biological effects of novel HDAC6 selective inhibitors

Synthesis of oxidative metabolites of the persistent organic pollutant DEHP

Synthesis of 4-N-alkyl gemcitabine analog bearing β-keto tosylate moiety suitable for 18F-labeling

Stepwise two-photon activatable BODIPY for multi-channel imaging in developing embryos

Light induced cell migration in vivo with photocaged TLR agonist

Synthesis and evaluation of a novel class of androgen receptor signaling axis inhibitors targeting castration-resistant prostate cancer

Biologically-Related Molecules & Processes

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Process research and development of the commercial synthesis of BTK inhibitor GDC-0853